Localization of the type 3 iodothyronine deiodinase (DIO3) gene to human chromosome 14q32 and mouse chromosome 12F1.
نویسندگان
چکیده
1. Bray-Ward, P., Menninger, J., Lieman, J., Desai, T., Mokady, N., Banks, A., and Ward, C. (1996). Integration of cytogenetic, genetic, and physical maps of the human genome by FISH mapping of CEPH YAC clones. Genomics 32: 1–14. 2. Oosterwijk, E., Ruiter, D. J., Hoedemaeker, P. J., Pauwels, E. K. J., Jonas, U., Zwartendijk, J., and Warnaar, S. O. (1986). Monoclonal antibody G250 recognizes a determinant present in renal-cell carcinoma and absent from normal kidney. Int. J. Cancer 38: 489–494. 3. Pastorek, J., Pastoreková, S., Callebaut, I., Mornon, J. P., Zelnı́k, V., Opavsky, R., Zat’ovicová, M., Liao, S., Pertetelle, D., Stanbridge, E. J., Závada, J., Burny, A., and Kettmann, R. (1994). Cloning and characterization of MN, a human tumorassociated protein with a domain homologous to carbonic anhydrase and a putative helix–loop–helix DNA binding segment. Oncogene 9: 2877–2888. 4. Pastoreková, S., Závadová, Z., Kost’al, M., Babusı́ková, O., and Závada, J. (1992). A novel quasi-viral agent, TaTu, is a twocomponent system. Virology 187: 620–626. 5. Závada, J., Závadová, Z., Malir, A., and Kocent, A. (1972). VSV pseudotype produced in cell line derived from human mammary carcinoma. Nat. New Biol. 240: 124–125.
منابع مشابه
Genomic Imprinting Contributes to Thyroid Hormone Metabolism in the Mouse Embryo
Many genes subject to genomic imprinting function in a number of endocrine/paracrine pathways that are important for normal mammalian development. Here, we show that an endocrine/paracrine pathway involving thyroid hormone metabolism is also regulated by imprinting. Thyroid hormone action depends on thyroid hormone receptors and their predominant ligand, 3,5,3'-triiodothyronine (T3). In vivo, t...
متن کاملCrystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism.
Local levels of active thyroid hormone (3,3',5-triiodothyronine) are controlled by the action of activating and inactivating iodothyronine deiodinase enzymes. Deiodinases are selenocysteine-dependent membrane proteins catalyzing the reductive elimination of iodide from iodothyronines through a poorly understood mechanism. We solved the crystal structure of the catalytic domain of mouse deiodina...
متن کاملIsolation and characterization of the mouse gene for the type 3 iodothyronine deiodinase.
The type 3 iodothyronine deiodinase (D3) is a selenoenzyme that inactivates thyroid hormones by removing a iodine from the 5-position of the tyrosyl ring. D3 is highly expressed in many tissues during the early stages of development, and its activity is regulated by selected growth factors and various hormones. To gain further insights into the structure, functional role, and regulation of this...
متن کاملPhotoperiod history-dependent responses to intermediate day lengths engage hypothalamic iodothyronine deiodinase type III mRNA expression.
Perihypothalamic thyroid hormone signaling features prominently in the seasonal control of reproductive physiology. Triiodothyronine (T(3)) signaling stimulates gonadal development, and decrements in T(3) signaling are associated with gonadal regression. Type 3 iodothyronine deiodinase (DIO3) converts the prohormone thyroxine (T(4)) into biologically inactive 3,3',5'-triiodothyronine, and in lo...
متن کاملRapid induction of hypothalamic iodothyronine deiodinase expression by photoperiod and melatonin in juvenile Siberian hamsters (Phodopus sungorus).
Production of T(3) in the mediobasal hypothalamus is critical for regulation of seasonal reproductive physiology. Type 2 iodothyronine deiodinase (DIO2) and DIO3 enzymes catalyze the prohormone T(4) into biologically-active T(3) and biologically-inactive rT(3), respectively. In several seasonally-breeding vertebrates, DIO2 and DIO3 expression is implicated in photoperiod signal transduction in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Genomics
دوره 53 1 شماره
صفحات -
تاریخ انتشار 1998